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  • Home
  • Cell Death Mechanisms
SLC7A11 SLC3A2 GPX4 System X c - Cystine Cysteine Lipid Peroxides Lipid ROS Ferroptosis Lipid Alcohols Glutamate GSH GSSG Fe 2+ Fenton Reaction SLC7A11 SLC3A2 GLUT System X c - F-actin collapse F-actin Glutamate Cystine Cysteine NADPH NADP+ Low glucose Disufide stress Reduction Disulfidptosis Casp 9 Casp 8/10 Casp 3/7 Bcl-XL BCL2 FADD APAF1 Cyto c BAK BAX Death ligands ( FasL or TNF-alpha, etc.) Stimuli ( DNA damage, etc.) BID tBID Apoptosis Apoptosome BH3 only protein RIPK1 RIPK3 RIPK1 RIPK3 MLKL MLKL MLKL MLKL P P P P P P P Necroptosis Casp 8 Ca 2+ Ca 2+ Na + Na + FADD Inhibition of Casp 8 Death ligands ( FasL or TNF-alpha, etc.) Oligomerisation of MLKL GSDMD IL-1β IL-18 IL-1β IL-18 GSDMD Casp 1 Casp 4/5 Inflammasome GSDMD pore LPS N-terminal Pyroptosis Cleavage Cleavage SLC31A1 ATP7A/B FDX1 DLAT DLAT LIAS Cu + Cu + Cu 2+ Cu 2+ Cu + Cu + Cu + Cuproptosis Lipoylation -ss DLAT -ss DLAT -ss Fe-S cluster proteins Oligomerizationof DLAT

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