- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human BMP-7 protein
Cat no : HZ-1229
Synonyms
BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, HZ1229, OP 1, OP1, Osteogenic protein 1
Validation Data Gallery
Technical Specifications
| GeneID | 655 |
| Species | Human |
| Expression | HEK293 |
| Activity(Primary) | 50-275 ng/mL |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P18075 |
| Molecular Mass | 20 kDa reduced, 32 to 36 kDa non-reduced, homodimer, glycosylated |
| Formulation | 10mM Acetic Acid |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in 10mM Acetic Acid containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
Bone morphogenetic protein-7 (BMP7), also known as osteogenic protein-1 or OP-1, plays a key role in the differentiation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in several cancers, including breast, prostate, and colon cancers (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients is significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
Synonyms
BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, HZ1229, OP 1, OP1, Osteogenic protein 1
Publications
| Species | Title |
|---|---|
Stem Cell Res Ther Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation. | |
J Tissue Eng Regen Med An Easy Long-acting BMP7 Release System Based on Biopolymer Nanoparticles for Inducing Osteogenic Differentiation of Adipose Mesenchymal Stem Cells. | |
Biochem Biophys Res Commun Angiopoietin-like 4 enhances metastasis and inhibits apoptosis via inducing bone morphogenetic protein 7 in colorectal cancer cells. | |
Biomed Mater Osteogenic differentiation system based on biopolymer nanoparticles for stem cells in simulated microgravity. | |
Regen Med Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates. |
Reviews
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Alessandro (Verified Customer) (07-27-2022) | Reliable supplement for dopaminergic neurons maturation
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FH Raffaele (Verified Customer) (06-06-2022) | Very good product, used at IC50 concentration is efficient, we register both morphological and molecular changes with very low mortality.
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