alpha-synuclein Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 10842-1-AP

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, human brain tissue, mouse brain tissue, SH-SY5Y cells

Positive IHC detected in:
human brain tissue, human brain tissue, human breast cancer tissue, human kidney tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue

Positive IF detected in:
SH-SY5Y cells, mouse brain tissue

Recommended dilution:
WB : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
synuclein, alpha (non A4 component of amyloid precursor)

Calculated molecular weight:
14 kDa

Observed molecular weight:
15-19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

Alpha synuclein, NACP, PARK1, PARK4, SNCA

alpha-synuclein (α-syn) is a 14-19 kDa phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation was identified as a cause of familial Parkinson’s disease (PD). Aggregated and hyper-phosphorylated forms of α-syn protein are the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV). This antibody can recognize all the isoforms of α-syn.

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