Activation Inhibition Translocation Phosphorylation Ubiquitin Ub P Endocytosis Cytoskeletalremodeling Apoptosis Cell growth Cell survival Gene expression Gene expression Cell motility RAS family DAG KRASNRASRRASMRASHRASERASNKIRAS1NKIRAS2RASL10ARASL10BRASL11ARASL11BRASL12 RERGRERGLRalARalBRAP1ARAP1BRAP2ARAP2BRAP2CRIT1RIT2... Integrin GPCR RTK PAK Rho AKT PI3K mTOR IKK RAC RAC CDC42 TIAM1 RAS RAS GRB2 SOS RAF RIN1 ABL1/2 RAB5A RASSF1/5 RALGDS RALGAP RalA/B RalA/B SEC5 TBK1 NF-κB MST1/2 MEK1/2 ERK1/2 RASGRF RASGEF PLGγ RASGRP RASGAP NF1 Gβ Gγ Gα GTP GTP GTP GDP GDP GDP Pi P P P P P P P P Cytoplasm Nucleus