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  • Wnt/Beta-Catenin signaling pathway
Wnt/ β -Catenin SIGNALING PATHWAY rev. 3/16/2023 Activation Inhibition Translocation Phosphorylation Ubiquitin U b P WNT Target Gene WNT Target Gene Inactive Canonical Wnt Noncanonical Wnt Active Proteasome Degradation Actin Polymerization Ca 2+ Dependent Pathway Frizzled Receptor Frizzled Receptor Frizzled Receptor CAMK2 APC TLE HDACs LRP5/6 DVL DVL PKC PLC CK1 α DAAM1 JNK RAC1 RhoA ROCK GSK3 β AXIN APC CK1 α GSK3 β AXIN β -TrCP CBP BCL9 NFAT JUN ATF2 NFAT TCF/LEF TCF/LEF WNT ROR/RYK DVL G-protein WNT β -Catenin β -Catenin β -Catenin β -Catenin β -Catenin P P P U b U b U b Cytoplasm Nucleus

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