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  • AMPK signaling pathway
Activation Inhibition Phosphorylation P CAMKK2 Ca 2+ EIF4E c-MYC SREBP1 RHEB Cyclin D 4EBP1 P P P P mTOR PRAS40 PDK1 IRS1/2 p70(S6K) AKT P P P TSC2 TSC1 HIF1α RPS6 PTEN PI3K FOXO3 TEAD BRAF RAS NF1 FOXO Raptor TGF-βReceptor RTK GPCR InsulinReceptor RTKs Leptin Insulin GLUT4 Glucose Autophagy P ATG13 P ATG9 DRP1 P MFF ULK1 FIP200 VPS34 TEAD ATG14L Beclin 1 VPS15 Lipid metabolism GLUT4 gene expression Cell GrowthandProtein metabolism PI3KC3 complex Malonyl CoA ACC HSL SREBP1 CPT1 FAS P STRAD MO25 LKB1 P AMPKα AMPKγ AMPKβ Glucose metabolism RAB PFKFB2 TORC2 GS CREB PGC1 α MEF2A SLC2A4RG TXNIP P TBC1D1 GLUT4Vesicle AMP P AMPK Catabolic Processes Glucase metabolism Autophapy Lipidoxidation ADP ATP Anabolic Processes Gluconeogenesisand glycogen storage Proteinsynthesis Lipidsynthesis ADP ATP

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