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  • PI3K-AKT signaling pathway
Activation Inhibition Translocation Phosphorylation Ubiquitin Ub P Translation Translationof mRNAs Glucosemetabolism GlucoseUptake Cell Cycle BlocksApoptosis CaspaseCascade PIP2 PIP3 mTORC2 mTORC1 Integrin CytokineReceptor GPCR BCR RTK CellSurvival RespiratoryBurst AggregationNeurodegeneration Neuroprotection CardiovascularHomeostasis NOProduction ERKPathway JNKPathway DNARepair NF-κBPathway 14-3-3 14-3-3 14-3-3 14-3-3 PTEN JAK1 SYK PDK1 TBK1 CTMP TRAF6 PP2A FAK ILK BCAP Paxillin AKT AKT PI3K PI3K PI3K PI3K PI3K IRS1 GAB1/2 GRB2 SOS RAS Raptor Deptor mLST8 PRAS40 mTOR GTP Gγ Gγ Gγ Protor Deptor mTOR mLST8 mSIN1 Rictor TSC2 4EBP1 p70(S6K) TSC1 RAF1 GSK3 AS160 p21,CIP1 p27,KIP1 GYS FOXO1 FOXO1 Caspase 9 XIAP BAD BAD p53 IKK MDM2 Cyclin D1 eNOS BRCA1 Ataxin p47 phox Huntingtin ASK1 PFKFB3 PFKM CREB1 YAP1 P P P P P P P P P P P P P P P P P P P P P

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