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  • MTOR signaling pathway
Activation Inhibition Translocation Phosphorylation Ubiquitin Ub P IRS1 PI3K PDK1 AMPK REDD1 GSK3β RAS SOS GRB2 RAF1 GRB10 RSK MEK1/2 ERK1/2 TBC1D7 PTEN AKT SGK1 PKC RHOA TSC1 TSC2 RHEB Protor Deptor mTOR mLST8 mSIN1 Rictor Raptor Deptor mTOR mLST8 PRAS40 p70(S6K) 4EBP1 HIF1α PGC1α PPARα PPARγ ULK1 ULK1 TFEB RPS6 EIF4B EIF4E Translation of mRNAs Glucosemetabolism Mitochondrialmetabolism Lipidmetabolism Adipogenesis Lysosomemetabolism Autophagy PIP2 PIP3 mTORC2 Lysosome v-ATPase SLC38A9 Ragulator Amino Acids Leucine Arginine Hypoxia Wnt Energy stress Growth Factors CellSurvival CellMigration ActinCytoskeleton Cell Growth Cap-dependenttranslocation mTORC1 Sestrin1/2 CASTOR1 CASTOR2 GATOR2 GATOR1 RagA/B GTP GDP RagC/D P P P P P P P P P P P P P P P P P P P P P P P P P P

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