• Featured Product
  • KD/KO Validated

APOBEC3C Polyclonal antibody

APOBEC3C Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 10591-1-AP

Synonyms

APOBEC1 like, APOBEC1L, APOBEC3, APOBEC3C, ARDC2, ARDC4, ARP5, bK150C2.3, PBI, Phorbolin I



Tested Applications

Positive WB detected inCaco-2 cells, HEK-293 cells, K-562 cells, SW480 cells
Positive IHC detected inhuman ovary tumor tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:100-1:400
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10591-1-AP targets APOBEC3C in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen APOBEC3C fusion protein Ag0886
Full Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Calculated Molecular Weight 23 kDa
Observed Molecular Weight 23 kDa
GenBank Accession NumberBC011739
Gene Symbol APOBEC3C
Gene ID (NCBI) 27350
RRIDAB_2057393
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

APOBEC3C(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C) is also named as APOBEC1L, PBI and belongs to the cytidine and deoxycytidylate deaminase family.APOBEC3C is related to APOBEC1, a cytidine deaminase responsible for cytidine-to-uridine editing of apolipoprotein B (APOB)mRNA.It can form a dimer(PMID:19074429).

Protocols

Product Specific Protocols
WB protocol for APOBEC3C antibody 10591-1-APDownload protocol
IHC protocol for APOBEC3C antibody 10591-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

J Exp Med

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.

Authors - Emily K Law
humanWB

Nucleic Acids Res

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G.

Authors - Zhaolong Li
humanIHC

Oncogenesis

Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma.

Authors - Yunzhen Qian
humanIHC

Sci Rep

Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.

Authors - Noriko Seishima
humanWB

J Virol

Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.

Authors - Noémie Lejeune
humanWB

Retrovirology

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

Authors - Brett D Anderson