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HumanKine® Human Cell-expressed Proteins

HumanKine® recombinant proteins are created in HEK293 cells using animal-free components.

  • High bioactivity & stability

  • Lot-to-lot consistency 

  • Native human conformation & post-translational modifications

  • Endotoxin-free, xeno-free & tag-free

All HumanKine® recombinant proteins are produced in Proteintech’s in-house GMP grade laboratory adhering to strict quality control regulations. Find out more here

Superior quality recombinant proteins are key to assuring the performance and commercial success of advanced therapies. Proteintech's GMP-grade and Research-grade HumanKine® recombinant proteins are well validated and proven to be stable, safe, pure and potent.

Browse all HumanKine® recombinant cytokines and growth factors
View our GMP Grade HumanKine® cytokines and growth factors

All HumanKine® recombinant proteins  are generated in HEK293 cells. The use of human expression system guarantees that the HumanKine® proteins have native conformation and post translational modifications which ensures the optimum activity of the protein. These proteins are expressed and purified without any tags.

Animal component free (ACF), xeno free (XF) and tag free (TF) policy

Driven by the desire for improved product consistency and safety of our products, we follow a strict  animal component free (ACF), xeno free (XF) and tag free (TF) policy.

Discover the benefits of animal component free (ACF), tag free (Tf), and xeno-free (XF) recombinant proteins here

Benefits of HumanKine® recombinant proteins

Recombinant proteins are proteins encoded by a gene - recombinant DNA - that has previously been cloned in a system that supports the gene expression and translation of messenger RNA.

Proteins coexpressed in bacteria will not possess post-translational modifications, e.g., phosphorylation or glycosylation. For activity, many proteins require glycosylation and processing only available in eukaryotic systems. Human stem cell technology and CAR-T cell therapy also require culture media whose components must be animal component and xenobiotic free.

HumanKine® recombinant proteins are created in HEK293 cells using animal-free components. Our human expression system ensures that proteins have native conformation and post-translational modifications to optimize biological activity. No expression tags, xeno-free…just high quality proteins.

Browse all HumanKine® recombinant cytokines and growth factors
HumanKine® Human Cell-expressed Protein Whitepapers
Time-Saving Dendritic Cell Generation No Medium Change - Less Reagents With HumanKine® GM-CSF and HumanKine IL4 Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins
HumanKine® IL-23 100x More Potent For Induction of Human Th17 Cells HumanKine® IL-17 Effective Tool for Autoimmune Disease Research
Effective Polarization of Human Th17 Cells with Biologically Relevant HumanKine® TGFβ1, TGFβ2, and TGFβ3 Expressed in Human Cells Effective Differentiation of Th17 Cells With HumanKine® Cytokines Expressed in Human Cells
Efficient Induction of Th17 Cells with HumanKine® TGFβ1 HumanKine® Noggin Human Cell-expressed Glycosylated Disulfide-linked Homodimer


See below for a full list of HumanKine® products:
Product Name Catalog number Activity spec. Purity Citations
Activin A HZ-1138 ≤5 ng/mL EC50 >95% 16
beta NGF HZ-1222 ≤3 ng/mL EC50 >95%  
BMP-2 HZ-1128 ≤60 ng/mL EC50 >95% 21
BMP-4 HZ-1045 ≤10 ng/mL EC50 >95% 41
BMP-7 HZ-1229 ≤100 ng/mL EC50 >95% 6
Cystatin C HZ-1211 ≤5 µM IC50 >95%  
EPO HZ-1168 ≤2.5 ng/mL EC50 >95% 3
FGF Basic TS HZ-1285 ≤0.5 ng.mL EC50 >95% 8
FGF-4 HZ-1218 ≤1.25 ng/mL EC50 >95%  
FGF-7 (KGF) HZ-1100 ≤7.5 ng/mL EC50 >95% 1
FGF-8b HZ-1103 ≤10 ng/mL EC50 >95% 1
FLT3 Ligand HZ-1151 ≤0.8 ng/mL EC50 >95% 10
G-CSF HZ-1207 ≤0.1 ng/mL EC50 >95% 6
GDNF HZ-1311 ≤ 10 ng/mL  EC50 >95%  
GM-CSF HZ-1002 ≤0.5 ng/mL EC50 >95% 10
HGF HZ-1084 ≤20 ng/mL EC50 >95% 8
HGH HZ-1007 ≤0.5 ng/mL EC50 >95% 2
HSA HZ-3001 N/A >95%  
IFN alpha 2A HZ-1066 ≤0.4 ng/mL EC50 >95% 4
IFN alpha 2B HZ-1072 ≤0.12 ng/mL EC50 >95% 2
IFN beta HZ-1298 ≤0.1 ng/mL EC50 >95%  
IFN gamma HZ-1301 ≤0.05 ng/mL EC50 >95% 3
IL-1 beta HZ-1164 ≤0.05 ng/mL EC50 >95% 16
IL-2 HZ-1015 ≤5 ng/mL EC50 >95% 5
IL-3 HZ-1074 ≤2 ng/mL EC50 >95% 10
IL-4 HZ-1004 ≤0.6 ng/mL EC50 >95% 17
IL-6 HZ-1019 ≤0.5 ng/mL EC50 >95% 19
IL-7 HZ-1281 ≤1 ng/mL EC50 >95%  
IL-9 HZ-1240 ≤1 ng/mL EC50 >95% 2
IL-10 HZ-1145 ≤1.5 ng/mL EC50 >95%  
IL-12 HZ-1256 ≤2 ng/mL EC50 >95% 3
IL-17 (IL-17A) HZ-1113 ≤2 ng/mL EC50 >95% 3
IL-17F HZ-1116 ≤10 ng/mL EC50 >95%  
IL-23 HZ-1254 ≤4 ng/mL EC50 >95% 11
IL-27 HZ-1275 ≤12 ng/mL EC50 >95% 1
IL-28A HZ-1235 ≤5 ng/mL EC50 >95% 2
IL-28B HZ-1245 ≤1 ng/mL EC50 >95%
IL-29 HZ-1156 ≤5 ng/mL EC50 >95% 2
Lefty-1 HZ-1109 ≤40 ng/mL EC50 >95% 1
LIF HZ-1292 ≤0.2 ng/mL EC50 >95%  
M-CSF HZ-1192 ≤4 ng/mL EC50 >95% 5
Noggin HZ-1118 ≤15 ng/mL EC50 >95% 5
Oncostatin M HZ-1030 ≤1 ng/mL EC50 >95%
PDGF-aa HZ-1215 ≤10 ng/mL EC50 >95%  
PDGFbb HZ-1308  ≤3 ng/mL EC50 >95% 1
Pleiotrophin-PTN HZ-1278 N/A >95%  
pro-IGF-II HZ-1161 ≤50 ng/mL EC50 >95% 1
SCF HZ-1024 ≤25 ng/mL EC50 >95% 9
Sonic Hedgehog (SHH) HZ-1306 ≤350 ng/mL EC50 >90%
TGF beta 1 HZ-1011 ≤0.5 ng/mL EC50 >95% 82
TGF beta 2 HZ-1092 ≤0.5 ng/mL EC50 >95%  4
TGF beta 3 HZ-1090 ≤0.5 ng/mL EC50 >95% 8
Thrombin HZ-3010 N/A >95% 1
TNF alpha HZ-1014 ≤0.5 ng/mL EC50 >95%  9
TPO HZ-1248 ≤5 ng/mL EC50 >95% 2
VEGF 121 HZ-1204 ≤15 ng/mL EC50 >95%  14
VEGF 165 HZ-1038 ≤5 ng/mL EC50 >95%  11
Wnt3A HZ-1296 ≤20 ng/mL EC50 >90%  1

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