Cytokines and Growth Factors
Human cell (HEK293) expressed cytokines and growth factors with high bioactivity, stability, lot-to-lot consistency, and native human conformation & post-translational modifications.
Our human expression system ensures that proteins have native conformation and post-translational modifications to optimize biological activity. No expression tags, xeno-free…just high quality proteins.
Animal component free
Endotoxin free
Xeno free
Tag free
Carrier free
HumanKine® recombinant proteins are created in HEK293 cells using animal free components
Proteins co-expressed in bacteria will not possess post- translational modifications, e.g., phosphorylation or glycosylation. For activity, many proteins require glycosylation and processing available exclusively in eukaryotic systems; specifically human systems for authentic human proteins.
All Humankine® recombinant proteins are produced in Proteintech's in-house cGMP grade laboratory adhering to strict quality control regulations.
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Authentic human proteins
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Native human conformation & post-translational modifications
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High bioactivity & stability
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Seamless transition from research to cGMP
In order to facilitate a smooth transition from preclinical to clinical, Humankine® offers a wide range of Research Use Only (RUO) and cGMP grade recombinant proteins which are exclusively expressed and purified from HEK293 human cells. The RUO and cGMP products are both manufactured using the same expression systems, production process and operating procedures in a cGMP facility. This guarantees that there is no variability in the quality and performance of these products.
The key differentiator of our cGMP products from RUO is that we adhere to a rigorous quality process that is ISO13485 certified and cGMP compliant. The cGMP grade products come with extensive documentation, thorough QC testing and traceability. The RUO grade offers reliable products which are more cost-effective during early research and development.
cGMP Manufacturing Process
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Resources
Time-Saving Dendritic Cell Generation No Medium Change - Less Reagents With HumanKine® GM-CSF and HumanKine IL4
HumanKine® IL-23 100x More Potent For Induction of Human Th17 Cells
Effective Polarization of Human Th17 Cells with Biologically Relevant HumanKine® TGFβ1, TGFβ2, and TGFβ3 Expressed in Human Cells
Efficient Induction of Th17 Cells with HumanKine® TGFβ1
Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins
HumanKine® IL-17 Effective Tool for Autoimmune Disease Research
Effective Differentiation of Th17 Cells With HumanKine® Cytokines Expressed in Human Cells
HumanKine® Noggin Human Cell-expressed Glycosylated Disulfide-linked Homodimer
Mesenchymal Stem Cell
Wnt Signaling
Induced Pluripotent Stem Cell
TGF-beta Signaling
Haematopoietic Stem Cell
IL-6
BMP-2
Independent research demonstrates HEK293 derived BMP-2 is more active and stable than either E.coli or CHO derived BMP-2.
IL-2
Proteintech's HumanKine recombinant IL-2 is 40x more active than leading competitor product.
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Wnt3A
High purity, high activity Wnt3A, without the high price.
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Product Flyer
HumanKine Cytokines and Growth Factors.
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Product Flyer
cGMP Grade HumanKine Cytokines and Growth Factors.
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Recent Publications
Front. Bioeng. Biotechnol.
Mechano-Hypoxia Conditioning of Engineered Human Meniscus
Alexander R A Szojka
Br J Pharmacol
Yanhong Pan
Int Immunopharmacol
Siqi Shao
Proc Natl Acad Sci U S A
Takahiro Nishio
Nat Commun
Extracellular mRNA transported to the nucleus exerts translation-independent function
Takeshi Tomita
Articles
ISO 13485 certification - cGMP compliant proteins
Proteintech announces ISO 13485 Certification for its HumanKine® Human Cell-expressed Cytokines and Growth Factors.
Top 4 considerations when choosing your recombinant proteins
Due to the importance in cell culture and therapeutic systems, there are several considerations to evaluate when choosing a recombinant protein for your own cultures.
What do you get when you buy a cGMP-Grade product?
cGMP manufacturing, benefits, and ISO certifications explained.
6 reasons why HEK293 proteins are superior for clinical applications
Find out the benefits of HumanKine® recombinant proteins, cytokines and growth factors.
ISO 13485 certification - cGMP compliant proteins
Proteintech announces ISO 13485 Certification for its HumanKine® Human Cell-expressed Cytokines and Growth Factors.
Top 4 considerations when choosing your recombinant proteins
Due to the importance in cell culture and therapeutic systems, there are several considerations to evaluate when choosing a recombinant protein for your own cultures.
What do you get when you buy a cGMP-Grade product?
cGMP manufacturing, benefits, and ISO certifications explained.
6 reasons why HEK293 proteins are superior for clinical applications
Find out the benefits of HumanKine® recombinant proteins, cytokines and growth factors.
New cGMP Laboratory
Proteintech announces completion of its new cGMP laboratory.
FGF Basic TS
Thermostable FGF does not require media changes over the weekend.