Cytokines and Growth Factors

Human cell (HEK293) expressed cytokines and growth factors with high bioactivity, stability, lot-to-lot consistency, and native human conformation & post-translational modifications.

Our human expression system ensures that proteins have native conformation and post-translational modifications to optimize biological activity. No expression tags, xeno-free…just high quality proteins.

Animal component free

Endotoxin free

Xeno free

Tag free

Carrier free

HumanKine® recombinant proteins are created in HEK293 cells using animal free components

Proteins co-expressed in bacteria will not possess post- translational modifications, e.g., phosphorylation or glycosylation. For activity, many proteins require glycosylation and processing available exclusively in eukaryotic systems; specifically human systems for authentic human proteins.

All Humankine® recombinant proteins are produced in Proteintech's in-house cGMP grade laboratory adhering to strict quality control regulations.

  • Authentic human proteins

  • Native human conformation & post-translational modifications

  • High bioactivity & stability

  • Seamless transition from research to cGMP

In order to facilitate a smooth transition from preclinical to clinical, Humankine® offers a wide range of Research Use Only (RUO) and cGMP grade recombinant proteins which are exclusively expressed and purified from HEK293 human cells. The RUO and cGMP products are both manufactured using the same expression systems, production process and operating procedures in a cGMP facility. This guarantees that there is no variability in the quality and performance of these products. ​

The key differentiator of our cGMP products from RUO is that we adhere to a rigorous quality process that is ISO13485 certified and cGMP compliant. The cGMP grade products come with extensive documentation, thorough QC testing and traceability. The RUO grade offers reliable products which are more cost-effective during early research and development. ​

cGMP Manufacturing Process

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Resources

Time-Saving Dendritic Cell Generation No Medium Change - Less Reagents With HumanKine® GM-CSF and HumanKine IL4

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HumanKine® IL-23 100x More Potent For Induction of Human Th17 Cells


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Effective Polarization of Human Th17 Cells with Biologically Relevant HumanKine® TGFβ1, TGFβ2, and TGFβ3 Expressed in Human Cells

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Efficient Induction of Th17 Cells with HumanKine® TGFβ1


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Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins

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HumanKine® IL-17 Effective Tool for Autoimmune Disease Research


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Effective Differentiation of Th17 Cells With HumanKine® Cytokines Expressed in Human Cells

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HumanKine® Noggin Human Cell-expressed Glycosylated Disulfide-linked Homodimer

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Mesenchymal Stem Cell

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Wnt Signaling

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Induced Pluripotent Stem Cell

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TGF-beta Signaling

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Haematopoietic Stem Cell

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BMP-2

Independent research demonstrates HEK293 derived BMP-2 is more active and stable than either E.coli or CHO derived BMP-2.

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IL-2

Proteintech's HumanKine recombinant IL-2 is 40x more active than leading competitor product.

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Wnt3A

High purity, high activity Wnt3A, without the high price.


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Product Flyer

HumanKine Cytokines and Growth Factors.



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Product Flyer

cGMP Grade HumanKine Cytokines and Growth Factors.


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Recent Publications

Front. Bioeng. Biotechnol.

Mechano-Hypoxia Conditioning of Engineered Human Meniscus

Alexander R A Szojka