AXIN1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 16541-1-AP

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Con: 24 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HT-1080 cells, A431 cells, A549 cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
axin 1

Calculated molecular weight:
826aa,92 kDa;862aa,95 kDa

Observed molecular weight:
100-110kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AXIN1

Synonyms
AXIN, axin 1, AXIN1, Axis inhibition protein 1, hAxin
Background

Axis inhibition protein1 (AXIN1), also called AXIN, together with AXIN2 are multidoman scaffold proteins that negatively regulate Wnt signaling. AXIN1 is likely to function as a tumor suppressor. Under UV irradiation, AXIN1-HIPK2-TP53 complex forms. The complex also controls cell growth, apoptosis and development. Like AXIN2, AXIN1 undergoes poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2 followed by unbiquitination by RNF146 which leads to its degradation and subsequent activation of Wnt signaling. Its deubiquitination by USP34 is important for nuclear accumulation during Wnt signaling. Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibdy raised against the N-terminus of human AXIN1.


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