COPS2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66435-1-Ig |CloneNo.: 2H10E6

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Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
NIH/3T3 cells, C6 cells, RAW 264.7 cells, ROS1728 cells

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:2000-1:16000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

Calculated molecular weight:
52 kDa

Observed molecular weight:
52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
COPS2

Synonyms
ALIEN, Alien homolog, COPS2, CSN2, SGN2, Signalosome subunit 2, TR interacting protein 15, TRIP 15, TRIP15
Background

COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.


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