DDX46 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 16927-1-AP

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Freight/Packing

Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, NIH/3T3 cells

Positive IP detected in:
NIH/3T3 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Calculated molecular weight:
1031aa,117 kDa

Observed molecular weight:
120-125 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DDX46

Synonyms
DDX46, DEAD box protein 46, FLJ25329, KIAA0801, PRP5 homolog, PRPF5
Background

DDX46, also named as KIAA0801, is a 1031 amino acid protein, which belongs to the DEAD box helicase family. DDX46 has been shown to be required at the early step of pre-spliceosome assembly. It uses the energy released by the hydrolysis of ATP to rearrange local RNA-RNA or protein-RNA interactions. The nuclear DDX46 acted as a negative regulator of the antiviral innate response by recruiting the m6A‘eraser’ ALKBH5 to induce retention of antiviral innate mRNA in the nucleus.


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