HDAC2 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 12922-3-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, HepG2 cells, human kidney tissue, Jurkat cells, MCF-7 cells, rat liver tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human prostate cancer tissue, human breast cancer tissue, human testis tissue

Positive IF detected in:
HepG2 cells, Hela cells

Positive FC detected in:
HEK-293T cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
histone deacetylase 2

Calculated molecular weight:
582aa,65 kDa;488aa,55 kDa

Observed molecular weight:
55-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HDAC2

Synonyms
HD2, HDAC2, histone deacetylase 2, RPD3, YAF1
Background

Histone deacetylases(HDAC) are a class of enzymes that remove the acetyl groups from the lysine residues leading to the formation of a condensed and transcriptionally silenced chromatin.Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). At least 4 classes of HDAC were identified. As a class I HDAC, HDAC2 was primarily found in the nucleus. HDAC2 forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human HDAC2.


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