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|Author:||Eapen Shawn A SA|
Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation.
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ING2, also named as ING1L, belongs to the ING family and contains a PHD-type zinc finger. It is induced by the DNA-damaging agents etoposide and neocarzinostatin. As a candidate tumor suppressor, ING2 seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. It is a component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. Recent finding reported that ING2 regulates muscle differentiation by regulating chormatin remodeling program. Catalog#16186-1-AP is rabbit polyclonal antibdoy raised against specific ING2 polypeptides and detects p33ING2 but not other INGs.