LATS2-Specific Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 20276-1-AP

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
SGC-7901 cells, human brain tissue, human heart tissue, mouse brain tissue

Positive IHC detected in:
human heart tissue, human colon tissue, human heart tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
LATS, large tumor suppressor, homolog 2 (Drosophila)

Calculated molecular weight:
120 kDa

Observed molecular weight:
150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LATS2

Synonyms
FLJ13161, KPM, LATS2, Warts like kinase
Background

LATS2, also named as KPM, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. LATS2 is a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. It is a negative regulator of the androgen receptor. LATS2 has a calculated molecular mass of 120 kDa and an apparent molecular mass of 150 kDa (PMID: 10871863). The antibody is specific to LATS2.


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