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LYPLA2(lysophospholipase II) is also named as APT2(acyl-protein thioesterase 2) and belongs to the AB hydrolase 2 family. It may hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Two cytosolic acyl thioesterases(APT1 and APT2, genes LYPLA1 and LYPLA2, respectively) have been identified as palmitoyl thioesterases that depalmitoylate cytosolic cysteine residues of proteins(PMID:22399288).