NAMPT/PBEF Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66385-1-Ig |CloneNo.: 3D4D8

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human heart tissue, human skeletal muscle tissue, mouse skeletal muscle tissue, Neuro-2a cells, rat heart tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nicotinamide phosphoribosyltransferase

Calculated molecular weight:
52 kDa

Observed molecular weight:
52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NAMPT

Synonyms
1110035O14Rik, DKFZp666B131, NAmPRTase, NAMPT, PBEF, PBEF1, Pre B cell enhancing factor, VF, VISFATIN
Background

Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.


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