PDE8A Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 13956-1-AP

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
phosphodiesterase 8A

Calculated molecular weight:
93 kDa

Observed molecular weight:
93kd,88kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDE8A

Synonyms
FLJ16150, HsT19550, PDE8A, phosphodiesterase 8A
Background

PDE8A(high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A) belongs to the cyclic nucleotide phosphodiesterase family and PDE8 subfamily. PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence PKA activity during β-adrenergic receptor (βAR) activation in ventricular myocytes(PMID:20353794). The full length protein contains several sites for protein phosphorylation, N-glycosylation, N-myristoylation, and amidation. It has 5 isoforms produced by alternative splicing with the molecular mass of 93 kDa, 88 kDa, 51 kDa and the isoform 4 and 5 have the same molecular mass of 66 kDa.(PMID:11738832).


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