TLE1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11284-1-AP

Featured Product KD/KO validated

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human gliomas tissue

Recommended dilution:
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

Calculated molecular weight:
83 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLE1

Synonyms
E(Sp1) homolog, ESG, ESG1, GRG1, TLE1
Background

Transducin-like enhancer protein 1(TLE1) is a transcriptional corepressor. It can bind to and regress expression of many transcription factors such as NFkB, which is mediated by FOXA2, CTNNB1 and TCF family member in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Expression of TLE1 is highest in skeletal muscle and liver, moderate in placenta, heart, kidney, and spleen, and weak in all other tissues including brain.


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