USP18 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12153-1-AP

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Con: 30 μg/150 μl

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Tested Applications

Applications:
ELISA, WB
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Species specificity:
human

Positive WB detected in:
MCF-7

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ubiquitin specific peptidase 18

Calculated molecular weight:
372aa,43 kDa

Observed molecular weight:
43 kDa, 70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
USP18

Synonyms
43 kDa ISG15 specific protease, hUBP43, ISG43, Ubl thiolesterase 18, UBP43, USP18
Background

USP18(UBP43) is a 43 kDa protein that is known as an ISG15-deconjugating enzyme and an inhibitor of type I IFN signaling independent of its enzyme activity. USP18 can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. It can be detected two bands(apparent MW of 38 and 35 kDa), the faster migrating one results from proteolytic processing in human primary hepatocytes(PMID:21779393). Sometimes the 70 kDa band is showed on the SDS-PAGE that it is considered as the complex of ISG15 and USP18(PMID: 14673145).


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