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STAT2 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

IP, WB

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Cat No : 61651,61652 61651

Synonyms

STAT2, Signal Transducer And Activator Of Transcription 2, 113kDa, STAT113, Signal Transducer And Activator Of Transcription 2, 113kD, Interferon Alpha Induced Transcriptional Activator, ISGF-3, Signal Transducer And Activator Of Transcription 2, P113, p113, jak-stat, transcription activator, antibody, antibodies, polyclonal, pab, western blotting, wb, immunoprecipitation, ip, sample

Validation Data Gallery

  • STAT2 antibody (pAb) tested by Immunoprecipitation. 10 ul of STAT2 antibody was used to immunoprecipitate STAT2 from 400 ug of HeLa whole cell extract (lane 2). 10 ul of rabbit IgG was used as a negative control (lane 1). The immunoprecipitated protein was detected by Western blotting using the STAT2 antibody at a dilution of 1:1,000.

    STAT2 antibody (pAb) tested by Immunoprecipitation. 10 ul of STAT2 antibody was used to immunoprecipitate STAT2 from 400 ug of HeLa whole cell extract (lane 2). 10 ul of rabbit IgG was used as a negative control (lane 1). The immunoprecipitated protein was detected by Western blotting using the STAT2 antibody at a dilution of 1:1,000.

  • STAT2 antibody (pAb) tested by Western blot. Whole cell extract (20 ug) of Jurkat cells (Lane 1) or HeLa cells (Lane 2) probed with STAT2 antibody at a 1:1,000 dilution.

    STAT2 antibody (pAb) tested by Western blot. Whole cell extract (20 ug) of Jurkat cells (Lane 1) or HeLa cells (Lane 2) probed with STAT2 antibody at a 1:1,000 dilution.

Product Information

Tested Applications IP, WB

Applications Validated by Active Motif: IP: 10 ul per IP WB: 1:500 - 1:2,000 dilution
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a peptide within the C-terminal region of human STAT2.
Full Name STAT2 antibody (pAb)
Synonyms STAT2, Signal Transducer And Activator Of Transcription 2, 113kDa, STAT113, Signal Transducer And Activator Of Transcription 2, 113kD, Interferon Alpha Induced Transcriptional Activator, ISGF-3, Signal Transducer And Activator Of Transcription 2, P113, p113, jak-stat, transcription activator, antibody, antibodies, polyclonal, pab, western blotting, wb, immunoprecipitation, ip, sample
Molecular weight 110 kDa
GenBank accession numberNP_005410
RRIDAB_2793720
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

STAT2 (Signal Transducer And Activator Of Transcription 2, 113kDa) is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.