RabGEF1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12735-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
PC-3 cells, human brain tissue

Positive IHC detected in:
human endometrial cancer tissue

Positive IF detected in:
PC-3 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
RAB guanine nucleotide exchange factor (GEF) 1

Calculated molecular weight:
79 kDa or 57 kDa

Observed molecular weight:
57 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RABGEF1

Synonyms
FLJ32302, Rab5 GDP/GTP exchange factor, rabex 5, RABEX5, RABGEF1, RAP1
Background

RabGEF1 (Rabex-5) is a guanine nucleotide exchange factor (GEF) for the endocytic pathway regulator Rab5. RabGEF1 contains a Vps9 domain, an A20-like zinc finger (ZnF) domain, and a coiled coil domain (PMID: 17341663). RabGEF1 is involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. It is also implicated in tumorigenesis and in the development of certain human cancers (PMID: 25427001).


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