TIGIT Monoklonaler Antikörper
TIGIT Monoklonal Antikörper für FC
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
Maus
Anwendung
FC
Konjugation
Unkonjugiert
CloneNo.
1G9
Kat-Nr. : 65079-1-Ig
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
65079-1-Ig bindet in FC TIGIT und zeigt Reaktivität mit Maus
| Getestete Reaktivität | Maus |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | Cells |
| Vollständiger Name | T cell immunoreceptor with Ig and ITIM domains |
| GenBank-Zugangsnummer | NM_001146325 |
| Gene symbol | Tigit |
| Gene ID (NCBI) | 100043314 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Affinitätsreinigung |
| Lagerungspuffer | 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2. |
| Lagerungsbedingungen | Bei 2-8℃ lagern. |
Hintergrundinformationen
TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).
