Anticorps Monoclonal anti-TIGIT
TIGIT Monoclonal Antibody for FC
Hôte / Isotype
Mouse / IgG1
Réactivité testée
souris
Applications
FC
Conjugaison
Non conjugué
CloneNo.
1G9
N° de cat : 65079-1-Ig
Synonymes
Galerie de données de validation
Applications testées
Dilution recommandée
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Informations sur le produit
65079-1-Ig cible TIGIT dans les applications de FC et montre une réactivité avec des échantillons souris
| Réactivité | souris |
| Hôte / Isotype | Mouse / IgG1 |
| Clonalité | Monoclonal |
| Type | Anticorps |
| Immunogène | Cellules |
| Nom complet | T cell immunoreceptor with Ig and ITIM domains |
| Numéro d’acquisition GenBank | NM_001146325 |
| Symbole du gène | Tigit |
| Identification du gène (NCBI) | 100043314 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité |
| Tampon de stockage | 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2. |
| Conditions de stockage | Stocker à une température comprise entre 2 °C et 8 °C. |
Informations générales
TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).
