MEF2C Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18291-1-AP

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Freight/Packing

Con: 26 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human colon tissue

Positive IHC detected in:
human brain tissue, human kidney tissue, human ovary tissue, human placenta tissue, human spleen tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
myocyte enhancer factor 2C

Calculated molecular weight:
51 kDa

Observed molecular weight:
51kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MEF2C

Synonyms
MEF2C, myocyte enhancer factor 2C
Background

MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. The immunogen used is peptide from transcription repressor of MEF2C. This antibody can recognize the transcript variant 1, transcript variant 2 and transcript variant 5 of MEF2C.


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