Custom Antibody Services
Leveraging over two decades of experience in antibody development, Proteintech scientists can fulfill all your custom antibody needs starting from antigen design and synthesis to large-scale production, characterization and conjugation of your antibody. Moreover, our Antigen-Specific B-Cell Cloning & Engineering (ABCE™) platform enables multi-species recombinant antibody discovery of desired targets with a rapid turnaround.
+ Years
Antibody Development Experience
K+
In-house Manufactured Antibodies
K
Targets Covered
K+
Product Citations
20+ Years
Antibody Development Experience
15K+
In-house Manufactured Antibodies
13K
Targets Covered
200K+
Product Citations
What to Expect from Us

Flexible Customization Options

Stringent Quality Control

Ph.D. Level Technical Support

Data Confidentiality
Our Recombinant Platform
Proteintech’s Antigen-Specific B-Cell Cloning & Engineering (ABCE™) platform achieves stable and high expression of recombinant monoclonal antibodies by cloning antibody heavy and light chain sequences derived from antigen-specific B cells into high-yield expression vectors followed by their introduction into suitable mammalian expression systems. The ABCE™ platform relies on the isolation of antigen-specific B cells by multi-parametric FACS that leads to the generation of recombinant monoclonal antibodies with native VH-VL pairings which is critical for antibody specificity and functionality and is often lost in other approaches such as phage display. Moreover, higher number of positive clones can be obtained from a small number of cells and in a much shorter time using the single B-cell approach compared to traditional hybridoma-based approaches. In addition to facilitating the high-throughput development of our off-the-shelf Uni-rAb™ recombinant monoclonal antibodies, the ABCE™ platform offers the flexibility of multi-species antibody discovery of desired targets with a rapid turnaround.

Projected timeline for custom recombinant antibody development on the ABCE™ platform.
Our Services
Recombinant Antibody Development Services
Proteintech has the capability to develop highly specific recombinant monoclonal antibodies from a wide variety of host species utilizing its single B cell-based ABCE™ platform. We offer single B cell services for:
- Rabbit
- Mouse
- Rat
- Alpaca
- Sheep
- Chicken
- Other species
Custom VHH/Nanobody Services
We have extensive experience developing alpaca-derived recombinant VHHs (also known as single-domain antibodies or nanobodies), preferred for specific applications due to their smaller size, minimal label displacement, better tissue penetration and low immunogenicity. Proteintech specializes in a wide range of custom VHH/nanobody services including:
- Protein and DNA immunization
- Fast screening of a proprietary synthetic library
- Development of epitope and affinity optimized VHHs
- Site-specific conjugation
Custom Conjugation Services
Proteintech offers small to large scale custom antibody conjugation services with fully validated end products. Our scientists have the experience of developing thousands of conjugated antibodies in-house and can therefore help you with:
- Conjugation of various fluorescent dyes, enzymes, peptides and oligonucleotides
- Site-specific and stoichiometric conjugation
- Development of antibody-drug conjugates (ADCs)
Antibody Characterization/Validation Services
Proteintech can help you with a variety of characterization and functional assays to test the purity and performance of your antibodies including:
- ELISA and antibody pairing
- FACS binding and blocking
- Functional assays including WB, IP, IHC, IF & FC
- Neutralization test
- Affinity measurement
- EC50/IC50 measurement
Antibody Engineering Services
In addition to full-length antibodies, Proteintech can engineer a variety of other recombinant antibodies tailored to specific project needs including:
- Fab, F(ab’) fragments
- scFv, scFv-Fc, VHH-Fc
- Fc modifications including Fc silencing
- Chimeric antibodies
- Bi-specific antibodies
- PTM-specific antibodies
- Humanized antibodies
GMP Antibody Manufacturing Services
Proteintech can also support your GMP antibody needs for use in diagnostics, drug discovery and cell & gene therapy manufacturing. Our GMP antibody development services include:
- Production of antibodies in compliance with ISO 13485:2016
- Quality check at every step of development
- Raw material qualification
- Regulatory support and detailed documentation
Custom Formulation Services
Since our antibodies are manufactured in-house, we have the flexibility to deliver your antibodies in specific formulations tailored to your project needs. Proteintech can fulfill a variety of antibody formulation requests including:
- Carrier-free formulations for use on specialized platforms
- Ultra low endotoxin antibodies for in vivo use
- Other custom formulations upon request
- Specific antibody concentrations