Custom Antibody Services

Leveraging over two decades of experience in antibody development, Proteintech scientists can fulfill all your custom antibody needs starting from antigen design and synthesis to large-scale production, characterization and conjugation of your antibody. Moreover, our Antigen-Specific B-Cell Cloning & Engineering (ABCE™) platform enables multi-species recombinant antibody discovery of desired targets with a rapid turnaround.

+ Years

Antibody Development Experience

K+

In-house Manufactured Antibodies

K

Targets Covered

K+

Product Citations

20+ Years

Antibody Development Experience

15K+

In-house Manufactured Antibodies

13K

Targets Covered

200K+

Product Citations

What to Expect from Us

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Flexible Customization Options

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Stringent Quality Control

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Ph.D. Level Technical Support

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Data Confidentiality

Our Recombinant Platform

Proteintech’s Antigen-Specific B-Cell Cloning & Engineering (ABCE™) platform achieves stable and high expression of recombinant monoclonal antibodies by cloning antibody heavy and light chain sequences derived from antigen-specific B cells into high-yield expression vectors followed by their introduction into suitable mammalian expression systems. The ABCE™ platform relies on the isolation of antigen-specific B cells by multi-parametric FACS that leads to the generation of recombinant monoclonal antibodies with native VH-VL pairings which is critical for antibody specificity and functionality and is often lost in other approaches such as phage display. Moreover, higher number of positive clones can be obtained from a small number of cells and in a much shorter time using the single B-cell approach compared to traditional hybridoma-based approaches. In addition to facilitating the high-throughput development of our off-the-shelf Uni-rAb™ recombinant monoclonal antibodies, the ABCE™ platform offers the flexibility of multi-species antibody discovery of desired targets with a rapid turnaround. ​

Projected timeline for custom antibody development on the ABCE platform workflow graphic ​

Projected timeline for custom recombinant antibody development on the ABCE™ platform.

Our Services

Recombinant Antibody Development Services

Proteintech has the capability to develop highly specific recombinant monoclonal antibodies from a wide variety of host species utilizing its single B cell-based ABCE™ platform. We offer single B cell services for:

  • Rabbit
  • Mouse
  • Rat
  • Alpaca
  • Sheep
  • Chicken
  • Other species
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Custom VHH/Nanobody Services

We have extensive experience developing alpaca-derived recombinant VHHs (also known as single-domain antibodies or nanobodies), preferred for specific applications due to their smaller size, minimal label displacement, better tissue penetration and low immunogenicity. Proteintech specializes in a wide range of custom VHH/nanobody services including:

  • Protein and DNA immunization
  • Fast screening of a proprietary synthetic library​
  • Development of epitope and affinity optimized VHHs
  • Site-specific conjugation
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Custom Conjugation Services

Proteintech offers small to large scale custom antibody conjugation services with fully validated end products. Our scientists have the experience of developing thousands of conjugated antibodies in-house and can therefore help you with:

  • Conjugation of various fluorescent dyes, enzymes, peptides and oligonucleotides
  • Site-specific and stoichiometric conjugation ​
  • Development of antibody-drug conjugates (ADCs)​
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Antibody Characterization/Validation Services

Proteintech can help you with a variety of characterization and functional assays to test the purity and performance of your antibodies including:

  • ELISA and antibody pairing
  • FACS binding and blocking​
  • Functional assays including WB, IP, IHC, IF & FC
  • Neutralization test
  • ​Affinity measurement
  • EC50/IC50 measurement
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Antibody Engineering Services

In addition to full-length antibodies, Proteintech can engineer a variety of other recombinant antibodies tailored to specific project needs including:

  • Fab, F(ab’) fragments 
  • ​scFv, scFv-Fc, VHH-Fc
  • Fc modifications including Fc silencing
  • Chimeric antibodies
  • Bi-specific antibodies
  • PTM-specific antibodies
  • Humanized antibodies
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GMP Antibody Manufacturing Services

Proteintech can also support your GMP antibody needs for use in diagnostics, drug discovery and cell & gene therapy manufacturing. Our GMP antibody development services include:

  • Production of antibodies in compliance with ISO 13485:2016
  • Quality check at every step of development ​
  • Raw material qualification
  • Regulatory support and detailed documentation
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Custom Formulation Services

Since our antibodies are manufactured in-house, we have the flexibility to deliver your antibodies in specific formulations tailored to your project needs. Proteintech can fulfill a variety of antibody formulation requests including:

  • Carrier-free formulations for use on specialized platforms
  • Ultra low endotoxin antibodies for in vivo use ​​
  • Other custom formulations upon request ​
  • Specific antibody concentrations
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