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ABCB5 Polyklonaler Antikörper

ABCB5 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20703-1-PBS

Synonyme

P-glycoprotein ABCB5, EC:7.6.2.2, ATP-binding cassette sub-family B member 5, ABCB5beta, ABCB5alpha

Filter:
  • Western Blot (WB) analysis of various lysates using ABCB5 Polyclonal antibody (20703-1-AP)

    WB analysis using 20703-1-AP (same clone as 20703-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20703-1-AP (ABCB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20703-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20703-1-PBS bindet in WB, Indirect ELISA ABCB5 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name ATP-binding cassette, sub-family B (MDR/TAP), member 5
Berechnetes Molekulargewicht 90 kDa
Beobachtetes Molekulargewicht 90-110 kDa
GenBank-ZugangsnummerNM_178559
Gene symbol ABCB5
Gene ID (NCBI) 340273
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ABCB5 is an 812 amino acid multi-pass membrane protein and belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins (PMID: 15760339). ABCB5 is an Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells(PMID: 15899824, 15205344). ABCB5 acts as a marker of stem-like cells (CSC) in several malignancies and is responsible for the resistance to doxorubicin of a subset of malignant melanomas (PubMed:24934811, 15760339). Alternate splicing results in multiple transcript variants.