MRP1 Monoklonaler Antikörper
MRP1 Monoklonal Antikörper für WB, IF/ICC, ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human und mehr (1)
Anwendung
WB, IHC, IF/ICC, ELISA
Konjugation
Unkonjugiert
CloneNo.
1G4A2
Kat-Nr. : 67228-1-Ig
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in WB | ungekochte HepG2-Zellen, unboiled A549 cells |
| Erfolgreiche Detektion in IF/ICC | A549-Zellen |
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| Immunfluoreszenz (IF)/ICC | IF/ICC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| KD/KO | See 1 publications below |
| WB | See 17 publications below |
| IHC | See 3 publications below |
| IF | See 1 publications below |
Produktinformation
67228-1-Ig bindet in WB, IHC, IF/ICC, ELISA MRP1 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| In Publikationen genannte Reaktivität | human, Maus |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | MRP1 fusion protein Ag27048 |
| Vollständiger Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| Berechnetes Molekulargewicht | 172 kDa |
| Beobachtetes Molekulargewicht | 180-190 kDa |
| GenBank-Zugangsnummer | NM_004996 |
| Gene symbol | MRP1 |
| Gene ID (NCBI) | 4363 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | PBS with 0.02% sodium azide and 50% glycerol |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Multidrug resistant-associated protein 1 (MRP1; ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| WB protocol for MRP1 antibody 67228-1-Ig | Protokoll herunterladen |
| IF protocol for MRP1 antibody 67228-1-Ig | Protokoll herunterladen |
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |
Publikationen
| Species | Application | Title |
|---|---|---|
Environ Pollut Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium. | ||
Cancers (Basel) NCAPG2 Maintains Cancer Stemness and Promotes Erlotinib Resistance in Lung Adenocarcinoma | ||
Commun Chem Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
| ||
Front Cell Dev Biol Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway. | ||
Transl Oncol Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker | ||

