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ABCC5 Monoklonaler Antikörper

ABCC5 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2H10F11

Kat-Nr. : 67955-1-PBS

Synonyme

ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP

Filter:
  • Western Blot (WB) analysis of various lysates using ABCC5 Monoclonal antibody (67955-1-Ig)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Boiled and unboiled HepG2 lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using ABCC5 Monoclonal antibody (67955-1-Ig)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67955-1-PBS bindet in WB, Indirect ELISA ABCC5 und zeigt Reaktivität mit human, Ratten

Getestete Reaktivität human, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen ABCC5 fusion protein Ag31674
Vollständiger Name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Berechnetes Molekulargewicht 161 kDa
Beobachtetes Molekulargewicht180-200kDa
GenBank-ZugangsnummerNM_005688
Gene symbol ABCC5
Gene ID (NCBI) 10057
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).