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ABL1 Polyklonaler Antikörper

ABL1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29725-1-PBS

Synonyme

c ABL, p150, JTK7, EC:2.7.10.2, ABL

Filter:
  • Western Blot (WB) analysis of various lysates using ABL1 Polyclonal antibody (29725-1-AP)

    WB analysis using 29725-1-AP (same clone as 29725-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29725-1-AP (ABL1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29725-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

29725-1-PBS bindet in WB, Indirect ELISA ABL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name c-abl oncogene 1, receptor tyrosine kinase
Berechnetes Molekulargewicht 1149 aa, 125 kDa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerBC117451
Gene symbol ABL1
Gene ID (NCBI) 25
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ABL1, also named as ABL, JTK7, c-ABL and p150, belongs to the protein kinase superfamily, Tyr protein kinase family and ABL subfamily. ABL1 regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ABL1 localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. It regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. ABL1 catalyze the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).