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ACE2 Monoklonaler Antikörper
ACE2 Monoklonal Antikörper für WB, IHC, IF-P, Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human, Maus
Anwendung
WB, IHC, IF-P, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
2F12A4
Kat-Nr. : 66699-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66699-1-PBS bindet in WB, IHC, IF-P, Indirect ELISA ACE2 und zeigt Reaktivität mit human, Maus
Getestete Reaktivität | human, Maus |
Wirt / Isotyp | Maus / IgG1 |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | ACE2 fusion protein Ag15554 |
Vollständiger Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 |
Berechnetes Molekulargewicht | 805 aa, 92 kDa |
Beobachtetes Molekulargewicht | 120 kDa, 92 kDa |
GenBank-Zugangsnummer | BC048094 |
Gene symbol | ACE2 |
Gene ID (NCBI) | 59272 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-G-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455). The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation (PMID:16166094). Sometimes, several cleaved fragments can also be detected as 75kDa, 50 kDa or 37kDa (PMID: 29561187, 22009550, 30759273). It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm, however it accumulates in the nucleus during the mitosis (PMID: 1730413/PMID: 18292088).