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ACE2 Rekombinanter Antikörper

ACE2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250137D6

Kat-Nr. : 98508-1-PBS

Synonyme

ACE-related carboxypeptidase, Angiotensin-converting enzyme 2, EC:3.4.17.-, EC:3.4.17.23, Processed angiotensin-converting enzyme 2

Filter:
  • Flow cytometry (FC) experiment of Transfected HEK-293T cells using Anti-Mouse ACE2 Rabbit Recombinant Antibody (98508-1-RR)

    FC experiment of Transfected HEK-293T using 98508-1-RR (same clone as 98508-1-PBS)

    1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98508-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of Transfected HEK-293T cells using Anti-Mouse ACE2 Rabbit Recombinant Antibody (98508-1-RR)

    FC experiment of Transfected HEK-293T using 98508-1-RR (same clone as 98508-1-PBS)

    1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98508-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98508-1-RR

    Affinity and Kinetic Characterization of 98508-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98508-1-RR against Mouse ACE2 were performed. The affinity constant is 1.75 nM.

Geprüfte Anwendungen

Produktinformation

98508-1-PBS bindet in FC ACE2 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen ACE2 fusion protein Eg2834
Vollständiger Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Berechnetes Molekulargewicht92 kDa
GenBank-ZugangsnummerNM_001130513.1
Gene symbol Ace2
Gene ID (NCBI) 70008
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455).