ACE2 Rekombinanter Antikörper

ACE2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250137D6

Kat-Nr. : 98508-1-RR

Synonyme

ACE-related carboxypeptidase, Angiotensin-converting enzyme 2, EC:3.4.17.-, EC:3.4.17.23, Processed angiotensin-converting enzyme 2

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  FC experiment of Transfected HEK-293T using 98508-1-RR

  1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of Transfected HEK-293T using 98508-1-RR

  1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98508-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98508-1-RR against Mouse ACE2 were performed. The affinity constant is 1.75 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Transfected HEK-293T cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98508-1-RR bindet in FC ACE2 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: ACE2 fusion protein Eg2834
• Vollständiger Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
• Berechnetes Molekulargewicht: 92 kDa
• GenBank-Zugangsnummer: NM_001130513.1
• Gene symbol: Ace2
• Gene ID (NCBI): 70008
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455).