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ACVR1 Polyklonaler Antikörper

ACVR1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11108-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of mouse kidney tissue using ACVR1 Polyclonal antibody (11108-1-AP)

    WB analysis of mouse kidney using 11108-1-AP (same clone as 11108-1-PBS)

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with 11108-1-AP (ACVR1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11108-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11108-1-PBS bindet in WB, Indirect ELISA ACVR1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ACVR1 fusion protein Ag1556
Vollständiger Name activin A receptor, type I
Berechnetes Molekulargewicht 509 aa, 57 kDa
Beobachtetes Molekulargewicht57 kDa
GenBank-ZugangsnummerBC033867
Gene symbol ACVR1
Gene ID (NCBI) 90
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).