ACVR1 Monoklonaler Antikörper
ACVR1 Monoklonal Antikörper für ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human, Maus
Anwendung
ELISA
Konjugation
Unkonjugiert
CloneNo.
2G1B1
Kat-Nr. : 60014-1-Ig
Synonyme
Geprüfte Anwendungen
Produktinformation
60014-1-Ig bindet in ELISA ACVR1 und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | ACVR1 fusion protein Ag1556 |
| Vollständiger Name | activin A receptor, type I |
| Berechnetes Molekulargewicht | 509 aa, 57 kDa |
| Beobachtetes Molekulargewicht | 57 kDa |
| GenBank-Zugangsnummer | BC033867 |
| Gene symbol | ACVR1 |
| Gene ID (NCBI) | 90 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | PBS with 0.02% sodium azide and 50% glycerol |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).
