ACVRL1 Rekombinanter Antikörper

ACVRL1 Rekombinant Antikörper für IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

241686B9

Kat-Nr. : 84421-1-RR

Synonyme

ALK1, ALK 1, ACVRLK1, Activin receptor-like kinase 1, Activin receptor like kinase 1

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  IF Staining of Jurkat using 84421-1-RR

  Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using ACVRL1 antibody (84421-1-RR, Clone: 241686B9 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

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  Affinity and Kinetic Characterization of 84421-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84421-1-RR against Human ACVRL1 were performed. The affinity constant is 0.727 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF/ICC: Jurkat-Zellen

Empfohlene Verdünnung

• Immunfluoreszenz (IF)/ICC: IF/ICC : 1:125-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

84421-1-RR bindet in IF/ICC, ELISA ACVRL1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: FusionProtein
• Vollständiger Name: activin A receptor type II-like 1
• Berechnetes Molekulargewicht: 56 kDa
• GenBank-Zugangsnummer: BC042637
• Gene symbol: ACVRL1
• Gene ID (NCBI): 94
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.