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ADAMTS2 Rekombinanter Antikörper

ADAMTS2 Rekombinant Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241860B8

Kat-Nr. : 84476-6-PBS

Synonyme

ADAMTS-2, pNPI, PCPNI, PCINP, ADAMTS 2

Filter:
  • Western Blot (WB) analysis of various lysates using ADAMTS2 Recombinant antibody (84476-6-RR)

    WB analysis using 84476-6-RR (same clone as 84476-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84476-6-RR (ADAMTS2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84476-6-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A431 cells using ADAMTS2 Recombinant antibody (84476-6-RR)

    IF Staining of A431 using 84476-6-RR (same clone as 84476-6-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using ADAMTS2 antibody (84476-6-RR, Clone: 241860B8 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84476-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84476-6-RR

    Affinity and Kinetic Characterization of 84476-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84476-6-RR against Human ADAMTS2 were performed. The affinity constant is 0.472 nM.

Geprüfte Anwendungen

Produktinformation

84476-6-PBS bindet in WB, IF/ICC, Indirect ELISA ADAMTS2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen ADAMTS2 fusion protein Ag34957
Vollständiger Name ADAM metallopeptidase with thrombospondin type 1 motif, 2
Berechnetes Molekulargewicht135 kDa
Beobachtetes Molekulargewicht110~130 kDa
GenBank-ZugangsnummerNM_014244
Gene symbol ADAMTS2
Gene ID (NCBI) 9509
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) is a metalloproteinase that plays a key role in the processing of fibrillar procollagen precursors into mature collagen molecules by excising the amino-propeptide. ADAMTS-2 can, like the procollagen C-proteinases, be regulated by transforming growth factor-β1 (TGF-β1), with implications for mechanisms whereby this growth factor effects net increases in formation of extracellular matrix. Mutations in the ADAMTS-2 gene cause dermatosparaxis in human (dermatosparactic type of Ehlers-Danlos syndrome, also known as Ehlers-Danlos syndrome type VIIC). Human ADAMTS-2 has eight potential sites for Asn-linked glycosylation and other mammals (PMID: 16046392, 12646579).