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ADRB2 Polyklonaler Antikörper

ADRB2 Polyklonal Antikörper für WB, IF-P, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF-P, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29864-1-PBS

Synonyme

ADRB2R, ADRBR, B2AR, BAR, Beta 2 adrenergic receptor

Filter:
  • Western Blot (WB) analysis of various lysates using ADRB2 Polyclonal antibody (29864-1-AP)

    WB analysis using 29864-1-AP (same clone as 29864-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 29864-1-AP (ADRB2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29864-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using ADRB2 Polyclonal antibody (29864-1-AP)

    WB analysis using 29864-1-AP (same clone as 29864-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 29864-1-AP (ADRB2 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29864-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of mouse stomach tissue using ADRB2 Polyclonal antibody (29864-1-AP)

    IF Staining of mouse stomach using 29864-1-AP (same clone as 29864-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse stomach tissue using ADRB2 antibody (29864-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29864-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

29864-1-PBS bindet in WB, IF-P, Indirect ELISA ADRB2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ADRB2 fusion protein Ag32313
Vollständiger Name adrenergic, beta-2-, receptor, surface
Berechnetes Molekulargewicht46 kDa
Beobachtetes Molekulargewicht46-48 kDa
GenBank-ZugangsnummerBC012481
Gene symbol ADRB2
Gene ID (NCBI) 154
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Beta-2 adrenergic receptor (ADRB2), a member of the G protein-coupled receptor (GPCR) family, binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADRB2 is directly linked to one of its final effectors, the class C L-type Ca2+ channel, Cav1.2 (PMID: 11441182). This receptor-channel complex also contains a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase (PKA), and a counteracting phosphatase, PP2A. Different polymorphic forms, point mutations, and/or downregulation of the gene of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. This antibody detects ADRB2 with a molecular weight of 46-48 kDa as has been shown by some researches (PMID: 30542705; 35075132).