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AES Rekombinanter Antikörper

AES Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

240987D9

Kat-Nr. : 83878-5-PBS

Synonyme

TLE5, 240987D9, AES 1, AES 2, Amino-terminal enhancer of split

Filter:
  • Western Blot (WB) analysis of various lysates using AES Recombinant antibody (83878-5-RR)

    WB analysis using 83878-5-RR (same clone as 83878-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83878-5-RR (AES antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83878-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83878-5-RR

    Affinity and Kinetic Characterization of 83878-5-RR

    Biolayer interferometry (BLl) kinetic assays of 83878-5-RR against Human AES were performed. The affinity constant is 1.76 nM.

Geprüfte Anwendungen

Produktinformation

83878-5-PBS bindet in WB, ELISA AES und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen AES fusion protein Ag21021
Vollständiger Name amino-terminal enhancer of split
Berechnetes Molekulargewicht 264 aa, 29 kDa
Beobachtetes Molekulargewicht 22-29 kDa
GenBank-ZugangsnummerBC113735
Gene symbol AES
Gene ID (NCBI) 166
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Amino-terminal enhancer of split (AES), belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members in order to forcefully repress the expression of other family member genes. AES can repress NFkB-regulated gene expression and is believed to have a significant role in initiating and maintaining cell differentiation events. AES has been found to suppress local invasion and intravasation through inhibition of the Notch pathway, leading to preventing the metastatic spread of endogenous tumors(PMID: 33754069).