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AFF2 Polyklonaler Antikörper

AFF2 Polyklonal Antikörper für WB, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25414-1-PBS

Synonyme

AF4/FMR2 family member 2, FMR2, FMR2P, FRAXE, MRX2

Filter:
  • Western Blot (WB) analysis of various lysates using AFF2 Polyclonal antibody (25414-1-AP)

    WB analysis using 25414-1-AP (same clone as 25414-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25414-1-AP (AFF2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25414-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of SH-SY5Y cells using AFF2 Polyclonal antibody (25414-1-AP)

    IP experiment of SH-SY5Y using 25414-1-AP (same clone as 25414-1-PBS)

    IP result of anti-AFF2 (IP:25414-1-AP, 4ug; Detection:25414-1-AP 1:600) with SH-SY5Y cells lysate 1720 ug. This data was developed using the same antibody clone with 25414-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

25414-1-PBS bindet in WB, IP, Indirect ELISA AFF2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen AFF2 fusion protein Ag22225
Vollständiger Name AF4/FMR2 family, member 2
Berechnetes Molekulargewicht 1311 aa, 145 kDa
Beobachtetes Molekulargewicht145 kDa
GenBank-ZugangsnummerBC132683
Gene symbol AFF2
Gene ID (NCBI) 2334
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

AFF2 (OMIM* 300806) (also known as FMR2 gene), which encodes AF4/FMR2 family member 2, is a transcriptional factor and RNA-binding protein that plays an important role in transcriptional regulation, RNA splicing, mRNA processing, and nuclear speckle organization . AFF2 is highly conserved and abundantly expressed in human brain, being essential for brain development. Homozygous AFF2 knock-out mice showed abnormal central nervous system synaptic transmission, abnormal excitatory postsynaptic potential, and premature death (PMID: 35431806).