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AGRN Rekombinanter Antikörper

AGRN Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251295C12

Kat-Nr. : 86507-3-PBS

Synonyme

Agrin, Agrin C-terminal 110 kDa subunit, Agrin C-terminal 22 kDa fragment, Agrin C-terminal 90 kDa fragment, Agrin N-terminal 110 kDa subunit

Filter:
  • Western Blot (WB) analysis of various lysates using AGRN Recombinant antibody (86507-3-RR)

    WB analysis using 86507-3-RR (same clone as 86507-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86507-3-RR (AGRN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86507-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86507-3-PBS bindet in WB, Indirect ELISA AGRN und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen AGRN fusion protein Eg5123
Vollständiger Name agrin
Berechnetes Molekulargewicht215 kDa
Beobachtetes Molekulargewicht245 kDa
GenBank-ZugangsnummerNM_198576.4
Gene symbol AGRN
Gene ID (NCBI) 375790
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Agrin, a large heparan sulfate proteoglycan, is expressed in neuronal, as well as nonneuronal tissues (PMID:12671652). Nerve-derived agrin has been demonstrated to play an essential role in development and maintenance of the neuromuscular junction (PMID:16386415). The agrin gene encodes a protein of more than 2000 amino acids with predicted molecular weight of 225 kDa but can display as 600 kDa protein due to extensive N-terminal glycosylation (PMID:12671652). Neurotrypsin cleaves the proteoglycan agrin at two homologous, highly conserved sites, liberating a middle 90-kDa and a C-terminal 22-kDa fragment from the membrane or ECM-bound N-terminal moiety of agrin (PMID:18230682).