ALDH1L2 Polyklonaler Antikörper

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• KD/KO Validated

ALDH1L2 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21391-1-PBS

Synonyme

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  WB analysis using 21391-1-AP (same clone as 21391-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21391-1-AP (ALDH1L2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 21391-1-AP (same clone as 21391-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21391-1-AP (ALDH1L2 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas using 21391-1-AP (same clone as 21391-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 21391-1-AP (ALDH1L2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas using 21391-1-AP (same clone as 21391-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 21391-1-AP (ALDH1L2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

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  IHC staining of human heart using 21391-1-AP (same clone as 21391-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart slide using 21391-1-AP (ALDH1L2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 21391-1-AP (same clone as 21391-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart slide using 21391-1-AP (ALDH1L2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

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  IF Staining of A431 using 21391-1-AP (same clone as 21391-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A431 cells using ALDH1L2 antibody (21391-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 21391-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

21391-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA ALDH1L2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ALDH1L2 fusion protein Ag16046
• Vollständiger Name: aldehyde dehydrogenase 1 family, member L2
• Berechnetes Molekulargewicht: 923 aa, 102 kDa
• Beobachtetes Molekulargewicht: 102 kDa, 89 kDa
• GenBank-Zugangsnummer: BC103935
• Gene symbol: ALDH1L2
• Gene ID (NCBI): 160428
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ALDH1L2(Aldehyde dehydrogenase family 1 member L2) is also named as mitochondrial 10-FTHFDH, mtFDH and belongs to the aldehyde dehydrogenase family and ALDH1L subfamily. The ALDH1L2 gene has three transcriptional variants with the molecular weight of 102 kDa, 42 kDa and 89 kDa(PMID:19823103). It is a mitochondrial enzyme, a likely source of CO2 production from 10-formyltetrahydrofolate in mitochondria and playing an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell(PMID: 20498374). It also has dehydrogenase/hydrolase activities similar to cytosolic FDH (ALDH1L1). The native ALDH1L2 has been reported to exist as a dimer or tetramer(PMID:7822273).