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ALK Monoklonaler Antikörper

ALK Monoklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

7G9E3

Kat-Nr. : 60321-1-PBS

Synonyme

ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, TFG/ALK

Filter:
  • Immunohistochemistry (IHC) staining of human lymphoma tissue using ALK Monoclonal antibody (60321-1-Ig)

    IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lymphoma tissue using ALK Monoclonal antibody (60321-1-Ig)

    IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK/CD246 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

60321-1-PBS bindet in IHC, Indirect ELISA ALK und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen ALK fusion protein Ag21493
Vollständiger Name anaplastic lymphoma receptor tyrosine kinase
Berechnetes Molekulargewicht 1620 aa, 176 kDa
GenBank-ZugangsnummerNM_004304
Gene symbol ALK
Gene ID (NCBI) 238
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).