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ALKBH2 Polyklonaler Antikörper

ALKBH2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17809-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using ALKBH2 Polyclonal antibody (17809-1-AP)

    WB analysis using 17809-1-AP (same clone as 17809-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17809-1-AP (ALKBH2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17809-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

17809-1-PBS bindet in WB, Indirect ELISA ALKBH2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ALKBH2 fusion protein Ag12108
Vollständiger Name alkB, alkylation repair homolog 2 (E. coli)
Berechnetes Molekulargewicht 261 aa, 29 kDa
Beobachtetes Molekulargewicht30-35 kDa
GenBank-ZugangsnummerBC070489
Gene symbol ALKBH2
Gene ID (NCBI) 121642
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Escherichia coli AlkB is a DNA repair enzyme that represents the founding member of the AlkB family of non-heme iron-dependent dioxygenases. The human genome encodes nine AlkB homologs termed AlkB homolog 1 through 8 (ALKBH1 through 8) plus a ninth member termed fat mass and obesity associated (FTO). Bacterial AlkB as well as human ALKBH2 and ALKBH3 catalyze the direct reversal of DNA methylation damage through a distinct oxidative demethylation reaction. Importantly, ALKBH2 has been shown to play a role in DNA alkylation damage repair in human, mouse and plant cells. Full-length ALKBH2 has a molecular weight of about 30kDa and ALKBH2 variant encoded by an alternatively spliced transcript with a frameshift deletion of the C-terminal dioxygenase domain has a molecular weight of about 25kDa (PMID:22079122).