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AMN1 Polyklonaler Antikörper

AMN1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14694-1-PBS

Synonyme

AMN 1

Filter:
  • Western Blot (WB) analysis of human colon tissue using AMN1 Polyclonal antibody (14694-1-AP)

    WB analysis of human colon using 14694-1-AP (same clone as 14694-1-PBS)

    human colon tissue were subjected to SDS PAGE followed by western blot with 14694-1-AP (AMN1 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14694-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon cancer tissue using AMN1 Polyclonal antibody (14694-1-AP)

    IHC staining of human colon cancer using 14694-1-AP (same clone as 14694-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer using 14694-1-AP (AMN1 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 14694-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14694-1-PBS bindet in WB, IHC, Indirect ELISA AMN1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen AMN1 fusion protein Ag6257
Vollständiger Name antagonist of mitotic exit network 1 homolog (S. cerevisiae)
Berechnetes Molekulargewicht 28 kDa
Beobachtetes Molekulargewicht 28 kDa
GenBank-ZugangsnummerBC067906
Gene symbol AMN1
Gene ID (NCBI) 196394
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

AMN1, also known as the antagonist of mitotic exit network 1 homolog, is a protein-coding gene that plays a significant role in regulating cell division and mitotic exit in Saccharomyces cerevisiae (baker's yeast). AMN1 is an atypical F-box protein involved in the regulation of the MEN pathway. It acts as an antagonist by disrupting the formation of the Tem1/Cdc15 complex, which is crucial for mitotic exit. Specifically, AMN1 competes with Cdc15 for binding to Tem1, thereby turning off the MEN pathway. AMN1 is essential for cell separation after cytokinesis. It inhibits the transcription factor Ace2, leading to the downregulation of Ace2 target genes. This inhibition prevents septum cleavage and results in post-mitotic cell separation inhibition, causing cell clumping.