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ANAPC11 Polyklonaler Antikörper

ANAPC11 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15065-1-PBS

Synonyme

APC11, ANAPC 11, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p

Filter:
  • Western Blot (WB) analysis of various lysates using ANAPC11 Polyclonal antibody (15065-1-AP)

    WB analysis using 15065-1-AP (same clone as 15065-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 15065-1-AP (ANAPC11 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15065-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

15065-1-PBS bindet in WB, Indirect ELISA ANAPC11 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ANAPC11 fusion protein Ag7069
Vollständiger Name anaphase promoting complex subunit 11
Berechnetes Molekulargewicht21 kDa, 10 kDa
Beobachtetes Molekulargewicht 21 kDa
GenBank-ZugangsnummerBC000607
Gene symbol APC11
Gene ID (NCBI) 51529
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Anaphase-promoting complex subunit 11 (ANAPC11) is a core catalytic subunit of the anaphase-promoting complex/cyclosome (APC/C). ANAPC11 is involved in the ubiquitination and degradation of key cell cycle regulators, including cyclin B and securin, facilitating the transition from metaphase to anaphase during cell division (PMID: 11739784; 18485873). ANAPC11 also mediates the ubiquitination and degradation of the Forkhead transcription factor FOXO3, promoting cell proliferation and lymph node metastasis in urothelial bladder cancer (PMID: 37573356).