APC Rekombinanter Antikörper

APC Rekombinant Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242726D4

Kat-Nr. : 85372-1-PBS

Synonyme

adenomatous polyposis coli, Adenomatous polyposis coli protein, DP2.5

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  IHC staining of human colon using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

85372-1-PBS bindet in IHC, Indirect ELISA APC und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: adenomatous polyposis coli
• Berechnetes Molekulargewicht: 312 kDa
• GenBank-Zugangsnummer: NM_000038
• Gene symbol: APC
• Gene ID (NCBI): 324
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

APC, also named as DP2.5, belongs to the adenomatous polyposis coli (APC) family. APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. APC promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. APC activity is correlated with its phosphorylation state. Defects in APC are a cause of familial adenomatous polyposis (FAP) which includes also Gardner syndrome (GS). Defects in APC are a cause of hereditary desmoid disease (HDD) which also known as familial infiltrative fibromatosis (FIF). Defects in APC are a cause of medulloblastoma (MDB) which is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) which also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1).