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APP Monoklonaler Antikörper
APP Monoklonal Antikörper für WB, IHC, Indirect ELISA
Wirt / Isotyp
Maus / IgG2a
Getestete Reaktivität
Hausschwein, human, Kaninchen, Ratte
Anwendung
WB, IHC, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
5C2A1
Kat-Nr. : 60342-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60342-1-PBS bindet in WB, IHC, Indirect ELISA APP und zeigt Reaktivität mit Hausschwein, human, Kaninchen, Ratten
Getestete Reaktivität | Hausschwein, human, Kaninchen, Ratte |
Wirt / Isotyp | Maus / IgG2a |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | APP fusion protein Ag0769 |
Vollständiger Name | amyloid beta (A4) precursor protein |
Berechnetes Molekulargewicht | 87 kDa |
Beobachtetes Molekulargewicht | 100 kDa |
GenBank-Zugangsnummer | BC004369 |
Gene symbol | APP |
Gene ID (NCBI) | 351 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).