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APP Rekombinanter Antikörper

APP Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251785E2

Kat-Nr. : 86777-1-PBS

Synonyme

amyloid precursor protein, A4 amyloid protein, AB40, AB42, AD1

Filter:
  • Western Blot (WB) analysis of various lysates using APP Recombinant monoclonal antibody (86777-1-RR)

    WB analysis using 86777-1-RR (same clone as 86777-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86777-1-RR (total APP antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86777-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86777-1-PBS bindet in WB, Indirect ELISA APP und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name amyloid beta (A4) precursor protein
Beobachtetes Molekulargewicht100-140 kDa
GenBank-ZugangsnummerBC065529
Gene symbol APP
Gene ID (NCBI) 351
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms.